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Immunology and Infection

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JoVE Journal Immunology and Infection
Identificatie van bemiddelaars/Mediators van T-cel Receptor signalering via de Screening van chemische remmer bibliotheken
Isolating Lymphocytes from the Mouse Small Intestinal Immune System
Journal (Immunology and Infection)
Isolating Lymphocytes from the Mouse Small Intestinal Immune System
User-friendly, High-throughput, and Fully Automated Data Acquisition Software for Single-particle Cryo-electron Microscopy
Journal (Immunology and Infection)
User-friendly, High-throughput, and Fully Automated Data Acquisition Software for Single-particle Cryo-electron Microscopy
 
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Identificatie van bemiddelaars/Mediators van T-cel Receptor signalering via de Screening van chemische remmer bibliotheken

Article DOI: 10.3791/58946-v • 08:49 min • January 22nd, 2019
January 22nd, 2019 •
*1, *2,3, *1, 1, 1,4
1Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 2Singapore Immunology Network, A*STAR, 3Curiox Biosystems, 4Department of Immunobiology, Rega Institute for Medical Research, Katholieke Universiteit (KU) Leuven
* These authors contributed equally

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Deze paper gebruikt een stroom cytometry-gebaseerde assay naar scherm bibliotheken van chemische inhibitoren voor de identificatie van remmers en de bijbehorende doelen die van invloed zijn T-cel receptor signalering. De hier beschreven methoden kunnen ook worden uitgebreid voor high-throughput screening.

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Immunologie en infecties probleem 143 activering van Caspase-3 kinase-remmers bibliotheek screening TCR signalering T-cel activatie thymocyte selectie
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