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Journal / Biochemistry / Menselijke perifere bloed neutrofiele isolatie…
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Biochemistry
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JoVE Journal Biochemistry
Menselijke perifere bloed neutrofiele isolatie voor het ondervragen van de Parkinson Geassocieerde LRRK2 Kinase Pathway door de beoordeling van Rab10 fosforylatie
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Menselijke perifere bloed neutrofiele isolatie voor het ondervragen van de Parkinson Geassocieerde LRRK2 Kinase Pathway door de beoordeling van Rab10 fosforylatie

Article DOI: 10.3791/58956-v • 12:49 min • March 21st, 2020
March 21st, 2020 •
*1, *1, 2, 2, 2, 3, 4, 5, 1, 1,6
1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, 2The Michael J. Fox Foundation for Parkinson's Research, 3Department of Medical and Molecular Genetics, Indiana University School of Medicine, 4Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University of Toronto, 5Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, 6Division of Molecular and Clinical Medicine, School of Medicine, Ninewells Hospital and Medical School, University of Dundee
* These authors contributed equally

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Mutaties in het leucine rijke reinase 2 gen (LRRK2) veroorzaken erfelijke de ziekte van Parkinson. We hebben een eenvoudige en robuuste methode ontwikkeld voor het beoordelen van LRRK2-gecontroleerde fosforylatie van Rab10 bij menselijke perifere bloedneutrofielen. Dit kan helpen bij het identificeren van personen met een verhoogde LRRK2 kinase traject activiteit.

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Biochemie Kwestie 157 De ziekte van Parkinson biomarkers LRRK2 kinase perifere bloedneutrofielen Rab eiwitten blaasjes handel eiwit fosforylatie
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