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Journal / Biochemistry / Isolamento de neutrófilos de sangue periférico…
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Biochemistry
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JoVE Journal Biochemistry
Isolamento de neutrófilos de sangue periférico humano para interrogar o Caminho Associado lRRK2 Kinase de Parkinson avaliando rab10 fosforilação
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Isolamento de neutrófilos de sangue periférico humano para interrogar o Caminho Associado lRRK2 Kinase de Parkinson avaliando rab10 fosforilação

Article DOI: 10.3791/58956-v • 12:49 min • March 21st, 2020
March 21st, 2020 •
*1, *1, 2, 2, 2, 3, 4, 5, 1, 1,6
1MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, 2The Michael J. Fox Foundation for Parkinson's Research, 3Department of Medical and Molecular Genetics, Indiana University School of Medicine, 4Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University of Toronto, 5Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, 6Division of Molecular and Clinical Medicine, School of Medicine, Ninewells Hospital and Medical School, University of Dundee
* These authors contributed equally

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Mutações no rico gene de leucina repetição quinase 2 (LRRK2) causam doença hereditária de Parkinson. Desenvolvemos um método fácil e robusto para avaliar a fosforilação controlada por LRRK2 de Rab10 em neutrófilos de sangue periféricos humanos. Isso pode ajudar a identificar indivíduos com aumento da atividade da via de quinase LRRK2.

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Bioquímica Edição 157 doença de Parkinson biomarcadores Quinase LRRK2 neutrófilos sanguíneos periféricos proteínas Rab tráfico de vesículas fosforilação protéica
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