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JoVE Journal Chemistry
Pretargeted Radioimmunotherapy baseret på Inverse elektron efterspørgsel Diels-elletræ reaktion
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Pretargeted Radioimmunotherapy baseret på Inverse elektron efterspørgsel Diels-elletræ reaktion

Article DOI: 10.3791/59041-v • 09:44 min • January 29th, 2019
January 29th, 2019 •
1,2, 1,2,3, 1,2,3,4
1Department of Chemistry, Hunter College of the City University of New York, 2Ph.D. Program in Chemistry, Graduate Center of the City University of New York, 3Department of Radiology, Memorial Sloan Kettering Cancer Center, 4Department of Radiology, Weill Cornell Medical College

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Denne protokol beskriver syntese og karakterisering af en trans- cyclooctene (TCO)-modificeret antistof og en 177Lu-mærket tetrazine (Tz) radioligand for pretargeted radioimmunotherapy (ANNS). Derudover detaljer det brugen af disse to konstruktioner til i vivo biodistribution og langsgående terapi undersøgelser i en murine model af kolorektal cancer.

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Kemi spørgsmålet 143 radioimmunotherapy pretargeted radioimmunotherapy pretargeting inverse elektron efterspørgsel Diels-elletræ reaktion tetrazine trans- cyclooctene huA33 A33 antigen lutetium 177
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