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JoVE Journal Chemistry
Pretargeted radio-immunothérapie basée sur la réaction de Diels-Alder demande Inverse d’électrons
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Pretargeted radio-immunothérapie basée sur la réaction de Diels-Alder demande Inverse d’électrons

Article DOI: 10.3791/59041-v • 09:44 min • January 29th, 2019
January 29th, 2019 •
1,2, 1,2,3, 1,2,3,4
1Department of Chemistry, Hunter College of the City University of New York, 2Ph.D. Program in Chemistry, Graduate Center of the City University of New York, 3Department of Radiology, Memorial Sloan Kettering Cancer Center, 4Department of Radiology, Weill Cornell Medical College

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Ce protocole décrit la synthèse et la caractérisation d’un trans- cyclooctène (TCO)-modification des anticorps et un radioligand de Lu marqué tetrazine (Tz) 177pour pretargeted radio-immunothérapie (Amel). En outre, il décrit en détail l’utilisation de ces deux concepts pour in vivo de biodistribution et études de thérapie longitudinale dans un modèle murin de cancer colorectal.

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Chimie numéro 143 immunothérapie pretargeted radio-immunothérapie pretargeting réaction de Diels-Alder la demande inverse d’électrons tetrazine trans- cyclooctène huA33 antigène A33 lutécium-177
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