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JoVE Journal Chemistry
Radioinmunoterapia pretargeted basada en la reacción de Diels-Alder de demanda electrónica inversa
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Radioinmunoterapia pretargeted basada en la reacción de Diels-Alder de demanda electrónica inversa

Article DOI: 10.3791/59041-v • 09:44 min • January 29th, 2019
January 29th, 2019 •
1,2, 1,2,3, 1,2,3,4
1Department of Chemistry, Hunter College of the City University of New York, 2Ph.D. Program in Chemistry, Graduate Center of the City University of New York, 3Department of Radiology, Memorial Sloan Kettering Cancer Center, 4Department of Radiology, Weill Cornell Medical College

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Este protocolo describe la síntesis y caracterización de un transporte- cyclooctene (TCO)-modifica un radioligando de Lu-labeled tetrazina (Tz) 177para radioinmunoterapia pretargeted (PRIT) y el anticuerpo. Además, detalla el uso de estas dos construcciones en vivo biodistribución y estudios longitudinales de la terapia en un modelo murino de cáncer colorrectal.

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Química número 143 radioinmunoterapia radioinmunoterapia pretargeted pretargeting reacción de Diels-Alder de demanda electrónica inversa tetrazina transporte- cyclooctene huA33 antígeno A33 Lutecio-177
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