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JoVE Journal Chemistry
Pretargeted radioimmunoterapi baserat på den inversa Electron efterfråge Diels-Alder reaktionen
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Pretargeted radioimmunoterapi baserat på den inversa Electron efterfråge Diels-Alder reaktionen

Article DOI: 10.3791/59041-v • 09:44 min • January 29th, 2019
January 29th, 2019 •
1,2, 1,2,3, 1,2,3,4
1Department of Chemistry, Hunter College of the City University of New York, 2Ph.D. Program in Chemistry, Graduate Center of the City University of New York, 3Department of Radiology, Memorial Sloan Kettering Cancer Center, 4Department of Radiology, Weill Cornell Medical College

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Det här protokollet beskriver syntes och karakterisering av en trans- cyclooctene (TCO)-den antikropp och en 177Lu-märkt tetrazine (Tz) radioligand för pretargeted radioimmunoterapi (PRIT). Dessutom specificerar det användning av dessa två konstruktioner för i vivo biodistribution och longitudinella studier i en murin modell av kolorektal cancer.

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Kemi fråga 143 radioimmunoterapi pretargeted radioimmunoterapi pretargeting omvänd elektron efterfrågan Diels-Alder-reaktionen tetrazine trans- cyclooctene huA33 A33 antigen lutetium-177
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