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En høj overførselshastighed Assay for forudsigelse af kemiske toksicitet af automatiseret fænotypiske profilering af Caenorhabditis elegans
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En høj overførselshastighed Assay for forudsigelse af kemiske toksicitet af automatiseret fænotypiske profilering af Caenorhabditis elegans

Article DOI: 10.3791/59082-v • 09:01 min • March 14th, 2019
March 14th, 2019 •
*1, *2, 1, 3, 1,4, 1,4, 1,4, 5, 5, 1, 3, 3, 1,4
1Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control/Beijing Center of Preventive Medicine Research, China, 2College of Computer Science and Technology, Qilu University of Technology(Shandong Academy of Sciences), China, 3Key Laboratory of Computational Biology, CAS Center for Excellence in Molecular Cell Science, Collaborative Innovation Center for Genetics and Developmental Biology, Chinese Academy of Sciences-Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China, 4Beijing Key Laboratory of Environmental Toxicology, School of Public Health, Capital Medical University, China, 5School of Life Sciences, La Trobe University, Australia
* These authors contributed equally

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En kvantitativ metode er blevet udviklet for at identificere og forudse kemikalier akutte toksicitet af automatisk analysere fænotypiske profilering af Caenorhabditis elegans. Denne protokol beskriver, hvordan du behandler orme med kemikalier i en 384-godt plade, fange videoer og kvantificere toksikologiske relaterede fænotyper.

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Miljøvidenskab sag 145 kemikalier toksicitet Caenorhabditis elegans billedanalyse fænotype kvantificering
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