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Immunology and Infection

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JoVE Journal Immunology and Infection
Um dispositivo de posicionamento para a colocação de camundongos durante a entrega de siRNA intranasal ao sistema nervoso central
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Um dispositivo de posicionamento para a colocação de camundongos durante a entrega de siRNA intranasal ao sistema nervoso central

Article DOI: 10.3791/59201-v • 05:28 min • August 15th, 2019
August 15th, 2019 •
1,2, 1, 2, 1, 2
1Department of Bioengineering and Institute of Nanoscience and Technology, Hanyang University, 2Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine

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Aqui, nós apresentamos um protocolo usando um dispositivo de posicionamento do rato que permita a colocação apropriada dos ratos para a administração intranasal de uma formulação do peptide-siRNA do cérebro-alvejando permitindo o silenciamento de gene eficaz no sistema nervoso central.

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Imunologia e infecção administração intranasal parto cerebral siRNA peptídeo RVG9R dispositivo de posicionamento do mouse nariz-a-cérebro
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