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Journal / Cancer Research / Patiënt-afgeleide Orthotopic xenograft modellen…
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JoVE Journal Cancer Research
Patiënt-afgeleide Orthotopic xenograft modellen voor humaan Urotheelcelcarcinoom en colorectale kanker tumor groei en spontane metastasen
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Patiënt-afgeleide Orthotopic xenograft modellen voor humaan Urotheelcelcarcinoom en colorectale kanker tumor groei en spontane metastasen

Article DOI: 10.3791/59223-v • 09:28 min • May 12th, 2019
May 12th, 2019 •
1, 1, 1, 2, 3, 3, 1, 2,4, 2,4, 3,4, 1,4
1Laboratory of Translational Cancer Research, Institute for Translational Research, Ochsner Clinic Foundation, 2Department of Urology, Ochsner Clinic Foundation, 3Department of Colon and Rectal Surgery, Ochsner Clinic Foundation, 4Ochsner Clinical School, University of Queensland, School of Medicine

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Dit protocol beschrijft de generatie van door patiënten afgeleide orthotopic xenotransplantaatmodellen is-modellen door intra-vesisch bijbrengen van hoogwaardige urotheelcelcarcinoom cellen of intra-rectale injectie van colorectale kankercellen in niet-zwaarlijvige diabetische/ernstige gecombineerde immunodeficiëntie (NOD/SCID) muizen voor primaire tumorgroei en spontane metastasen onder invloed van lymfeklier stromale cellen, die de progressie van humane gemetastaseerde ziekten nabootst.

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Kankeronderzoek probleem 147 patiënt-afgeleide orthotopic xenograft high-grade urotheelceltumoren celcarcinoom colorectale kanker lymfeklier stromale cellen metastase muismodel tumor micro omgeving
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