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JoVE Journal Neuroscience
Konveksjon Enhanced levering av Optogenetic Adeno-Associated viral Vector til cortex på rhesus macaque under veiledning av online MRI bilder
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Konveksjon Enhanced levering av Optogenetic Adeno-Associated viral Vector til cortex på rhesus macaque under veiledning av online MRI bilder

Article DOI: 10.3791/59232-v • 08:52 min • May 23rd, 2019
May 23rd, 2019 •
1,2, 2,3, 4, 1,2,3,4
1Departments of Bioengineering, University of Washington, 2Washington National Primate Research Center, 3Department of Electrical and Computer Engineering, University of Washington, 4Department of Physiology and Center for Integrative Neuroscience, University of California, San Francisco

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Her viser vi magnetisk resonans (MR)-guidet konveksjon forbedret levering (CED) av viral vektorer i cortex som en effektiv og forenklet tilnærming for å oppnå optogenetic uttrykk på tvers av store kortikale områder i macaque hjernen.

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Nevrovitenskap Optogenetics ikke-menneskelige primater rhesus aper viral vektor levering Opsin uttrykk primær motor cortex Primary somatosensory cortex
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