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Journal / Genetics / Intraventrikulær transplantation af konstruerede…
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Genetics
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JoVE Journal Genetics
Intraventrikulær transplantation af konstruerede neuronal prækursorer til in vivo Neuroarchitecture studier
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Intraventrikulær transplantation af konstruerede neuronal prækursorer til in vivo Neuroarchitecture studier

Article DOI: 10.3791/59242-v • 15:00 min • May 11th, 2019
May 11th, 2019 •
1, 1, 1
1Laboratory of Cerebral Cortex Development, SISSA

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Baseret på in vitro lentiviral engineering af neuronal prækursorer, deres Co-transplantation til vild-type hjerner og parret morphometrisk evaluering af "test" og "kontrol" derivater, denne metode giver præcis modellering af in vivo gen kontrol af neocortical neuron morfologi på en enkel og overkommelig måde.

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Genetik neuronal morfologi neurite genekspression transgene kontrol lentivirus intraventrikulær transplantation
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