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Journal / Neuroscience / Elektroforetisk levering af γ-aminosmørsyre…
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JoVE Journal Neuroscience
Elektroforetisk levering af γ-aminosmørsyre (GABA) til epileptisk fokus forhindrer krampeanfald i mus
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Elektroforetisk levering af γ-aminosmørsyre (GABA) til epileptisk fokus forhindrer krampeanfald i mus

Article DOI: 10.3791/59268-v • 07:01 min • May 16th, 2019
May 16th, 2019 •
*1,5, *2,3, 1,4, 2,3, 1,5
1Aix Marseille Université, Institut de Neurosciences des Systèmes (INS), 2Electrical Engineering Division, University of Cambridge, 3Department of Bioelectronics, Centre Microélectronique de Provence - Ecole Nationale Supérieure des Mines de Saint-Étienne (CMP-EMSE), 4Institut de Neurosciences de la Timone, Centre National de la Recherche Scientifique (CNRS) UMR 7289 & Aix- Marseille Université, 5Neuroengineering Research Group, Interdisciplinary Excellence Center, Department of Medical Microbiology and Immunobiology, University of Szeged
* These authors contributed equally

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Udfordringen ved epilepsi forskning er at udvikle nye behandlinger for patienter, hvor klassisk terapi er utilstrækkelig. Ved hjælp af en ny protokol — ved hjælp af et implantabelt lægemiddel levering system — vi er i stand til at kontrollere anfald i bedøvet mus ved elektroforetisk levering af GABA i epileptiske fokus.

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Neurovidenskab mikrofluidisk kapllærelektroforese ion pumpe μfip elektroforese epilepsi krampeanfald epileptisk fokus Gaba hippocampus silicium sonde 4-aminopyridin 4ap mus
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