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JoVE Journal Neuroscience
En in vitro model for at studere Tau aggregering ved hjælp af Lentiviral-medieret transduktion af humane neuroner
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En in vitro model for at studere Tau aggregering ved hjælp af Lentiviral-medieret transduktion af humane neuroner

Article DOI: 10.3791/59433-v • 05:51 min • May 23rd, 2019
May 23rd, 2019 •
1, 1, 1, 1
1Department of Neurosciences, University of California, San Diego

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Denne protokol beskriver en procedure, hvor menneskelige neuronal kulturer er transduceret med lentiviral konstruktioner kodning for mutant menneske Tau. Transduceret kulturer display Tau aggregater og tilknyttede patologier.

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Neurovidenskab Tau Neuron neurale stamceller Alzheimers sygdom frontotemporal demens neurodegeneration lentivirus tauopati
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