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Immunology and Infection

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JoVE Journal Immunology and Infection
En avanceret murine model for alkoholfri steatohepatitis i forbindelse med type 2 diabetes
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En avanceret murine model for alkoholfri steatohepatitis i forbindelse med type 2 diabetes

Article DOI: 10.3791/59470-v • 10:17 min • April 26th, 2019
April 26th, 2019 •
1,2,3,4, 3,6, 3,5, 3,5, *1,2,4, *2,3,5
1Department of Endocrinology & Metabolism Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 2Berlin Institute of Health (BIH), 3Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 4DZHK (German Centre for Cardiovascular Research), 5Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 6Julius Wolff Institute (JWI) and Center for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, Berlin, Germany, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin
* These authors contributed equally

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En enkel og pålidelig kost-induceret gnaver dyremodel for nonalkoholisk steatohepatitis (NASH) er beskrevet, opnået gennem ikke-SPF boliger af dyrene og administration af en bestemt fedtfattig diæt. Vi beskriver identifikation af hepatiske og fedtmæssige immuncelle undersæt for at rekapitulere humane immunologiske tilstande ved at udsætte mus for miljømæssige bakterier.

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Immunologi og infektion immunologi og miljømæssig eksponering fedme adaptiv immunologi insulinresistens boligforhold metabolisk fænotype flow cytometri
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