Waiting
Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Chemistry / Inactivación química del E3 Ubiquitin Ligase…
JoVE Journal
Chemistry

A subscription to JoVE is required to view this content.

JoVE Journal Chemistry
Inactivación química del E3 Ubiquitin Ligase Cereblon por Homo-PROTACs basados en Pomalidomida
Growth of Gold Dendritic Nanoforests on Titanium Nitride-coated Silicon Substrates
Journal (Chemistry)
Growth of Gold Dendritic Nanoforests on Titanium Nitride-coated Silicon Substrates
Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers (Video) | JoVE
Journal (Chemistry)
Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers (Video) | JoVE
 
Click here for the English version

Inactivación química del E3 Ubiquitin Ligase Cereblon por Homo-PROTACs basados en Pomalidomida

Article DOI: 10.3791/59472-v • 10:44 min • May 15th, 2019
May 15th, 2019 •
*1, *2, 1, 2, 2, 1
1Department of Internal Medicine III, University Hospital Ulm, 2Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn
* These authors contributed equally

Chapters

Summary
Automatic Translation

Please note that all translations are automatically generated.

Click here for the English version.

Este trabajo describe la síntesis y caracterización de un homo-PROTAC bifuncional basado en pomalidomida como un enfoque novedoso para inducir la ubiquitinación y degradación de la e3 ubiquitina ligreblon (CRBN), el objetivo de los análogos de la talidomida.

Tags

Química Número 147 CRBN PROTAC IMiD pomalidomida ubiquitina ligasa mieloma múltiple proteasoma
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter