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JoVE Journal Cancer Research
Patient-afledt heterogene xenograft model af kræft i bugspytkirtlen ved hjælp af Zebrafish larver som værter for sammenlignende Lægemiddelvurdering
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Patient-afledt heterogene xenograft model af kræft i bugspytkirtlen ved hjælp af Zebrafish larver som værter for sammenlignende Lægemiddelvurdering

Article DOI: 10.3791/59507-v • 09:56 min • April 30th, 2019
April 30th, 2019 •
*1, *2,3, *1, 2,3, 1, 1, 2,3, 2,4,5,6, 1
1Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Fudan University, 2National Human Genetic Resources Sharing Service Platform (2005DKA21300), 3Fudan University Shanghai Cancer Center, 4Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, 5Department of Oncology, Shanghai Medical College, Fudan University, 6Pancreatic Cancer Institute, Fudan University
* These authors contributed equally

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Denne protokol beskriver optimerings procedurer i en virus baseret Dual fluorescens-mærket tumor xenograft model ved hjælp af larve Zebra som værter. Denne heterogene xenograft model efterligner vævet sammensætning af bugspytkirtelkræft mikromiljø in vivo og fungerer som et mere præcist redskab til vurdering af narkotika respons i personlige zPDX (zebrafish patient-afledte xenograft) modeller.

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Kræftforskning kræftforskning tumor xenograft zebrafish pancreatisk karcinom in vivo Drug vurdering BCL2L1
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