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JoVE Journal Bioengineering
Voorbereiding van neutraal geladen, pH-responsieve polymere nanodeeltjes voor cytosolische siRNA levering
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Voorbereiding van neutraal geladen, pH-responsieve polymere nanodeeltjes voor cytosolische siRNA levering

Article DOI: 10.3791/59549-v • 09:09 min • May 2nd, 2019
May 2nd, 2019 •
1, 1, 1,2,3
1Department of Chemical Engineering, University of Mississippi, 2Department of BioMolecular Sciences, University of Mississippi, 3Biomedical Engineering Program, University of Mississippi

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Methoden ter voorbereiding en karakterisering van de fysisch-chemische eigenschappen en bioactiviteit van neutraal geladen, pH-responsieve siRNA nanodeeltjes worden gepresenteerd. De criteria voor succesvolle siRNA nanomedicines zoals grootte, morfologie, oppervlaktelast, siRNA lading, en gen het silencing worden besproken.

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Biotechniek kwestie 147 de interferentie van RNA Endosomale vlucht Endosomolysis pH-ontvankelijk nanotechnologie polymere nanodeeltjes biomedische techniek drug levering kanker
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