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Neuroscience

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JoVE Journal Neuroscience
Cibler les agrégats alpha synuclein dans les fibres nerveuses périphériques cutanées par l'évaluation de l'immunofluorescence flottante
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Cibler les agrégats alpha synuclein dans les fibres nerveuses périphériques cutanées par l'évaluation de l'immunofluorescence flottante

Article DOI: 10.3791/59558-v • 08:33 min • June 25th, 2019
June 25th, 2019 •
1, 1, 1,2,3,4, 1,2
1Laboratory for Biomedical Neurosciences, Neurocenter of Southern Switzerland, 2Neurology Department, Neurocenter of Southern Switzerland, 3Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 4Faculty of Biomedical Sciences, Università della Svizzera Italiana

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Ici, nous présentons un protocole pour un test d'immunofluorescence indirecte flottant sur les sections de biopsie de peau qui permet l'identification des variantes spécifiques de conformation de la maladie de la synuclein alpha impliquée dans la maladie de Parkinson et les protéines multiples du système nerveux périphérique.

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Neurosciences Numéro 148 biopsie de la peau Système nerveux périphérique immunofluorescence indirecte Free-floating Produit du gène protéique 9,5 alpha Synuclein Microuclein alpha phosphorylated 5G4 agrégats protéiques
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