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Neuroscience

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JoVE Journal Neuroscience
Transplantatie van Chemogenetisch gemanipuleerde corticale Interneuron progenitors in vroege postnatale Muizenhersenen
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Transplantatie van Chemogenetisch gemanipuleerde corticale Interneuron progenitors in vroege postnatale Muizenhersenen

Article DOI: 10.3791/59568-v • 06:09 min • August 26th, 2019
August 26th, 2019 •
1,2, 3, 3, 1
1Nervous System Development and Homeostasis Laboratory, The Francis Crick Institute, 2Neuroscience Centre, Biomedical Sciences Research Centre "Al. Fleming", 3Centre for Developmental Neurobiology, King's College London

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Hier presenteren we een protocol, ontworpen om gebruik te maken van chemogenetische hulpmiddelen om de activiteit van corticale Interneuron voorlopercellen getransplanteerd in de cortex van vroege postnatale muizen te manipuleren.

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Neuroscience probleem 150 corticale interneuronen ganglionaire Eminence brain slice electroporation intracraniële injecties Designer receptoren uitsluitend geactiveerd door designer drugs (dreadd)
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