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JoVE Journal Biology
Fremstilling af amyloid-β-udskilning af Alginat-Mikroperler til brug ved modellering af Alzheimers sygdom
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Fremstilling af amyloid-β-udskilning af Alginat-Mikroperler til brug ved modellering af Alzheimers sygdom

Article DOI: 10.3791/59597-v • 06:52 min • July 6th, 2019
July 6th, 2019 •
1, 2, 1, 1
1Division of Pharmacy and Optometry, School of Health Studies, Faculty of Biology, Medicine and Health, University of Manchester, 2Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester

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Denne protokol illustrerer en celle indkapsling metode ved hurtig fysisk gelering af alginat at immobilisere celler. Opnåede mikroperler tillader kontrolleret og vedvarende sekretion af amyloid-β over tid og kan anvendes til at studere virkningerne af udskillet amyloid-β i in vitro-og in vivo-modeller.

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Biologi Alzheimers sygdom amyloid Aβ hydrogels alginat indkapsling 3D in vitro-modeller kontrolleret frigivelse
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