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Journal / Medicine / A Rabbit Model of Aqueous-Deficient Dry Eye…
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JoVE Journal Medicine
A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Dlands
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A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Dlands: Application to Drug Efficacy Studies

Article DOI: 10.3791/59631-v • 08:04 min • January 24th, 2020
January 24th, 2020 •
1, 2,3, 2
1Department of Ophthalmology, Stony Brook University, 2Department of Preventive Medicine, Stony Brook University, 3Medicon Pharmaceuticals, Inc.

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Dieser Artikel beschreibt die Entwicklung einer Methode, um akute oder chronische trockene Augenerkrankungen bei Kaninchen zu induzieren, indem Concanavalin A in alle Teile des Orbital-Tränendrüsensystems injiziert wird. Diese Methode, die den bereits gemeldeten überlegen ist, erzeugt ein reproduzierbares, stabiles Modell des trockenen Auges, das für die Untersuchung pharmakologischer Wirkstoffe geeignet ist.

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Retraktion Ausgabe 155 trockenes Auge trockene Augenkrankheit Trockenes Augensyndrom Kaninchenmodell Concanavalin A Tränenbruchzeit Schirmers Tränentest Tränenosmolarität Rosabengalenfärbung okuläre Arzneimittelentwicklung
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