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Implantation av en Isoproterenol mini-Pump for å indusere hjertesvikt i mus
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Implantation av en Isoproterenol mini-Pump for å indusere hjertesvikt i mus

Article DOI: 10.3791/59646-v • 05:08 min • October 3rd, 2019
October 3rd, 2019 •
1, 2, 3, 4, 1, 2
1Department of Anesthesiology, University of California, 2Department of Medicine, University of California, 3Department of Microbiology, Immunology & Molecular Genetics, University of California, 4Department of Molecular, Cell, and Developmental Biology, University of California

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Den kroniske administrasjonen av isoproterenol via en implantert osmotisk-pumpe har blitt brukt mye til å etterligne avansert hjertesvikt hos mus. Her beskriver vi detaljerte metoder i kirurgisk mini-pumpe implantation for kontinuerlig isoproterenol administrasjon over 3 uker, samt echocardiographic vurdering for vellykket modell opprettelse.

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Medisin hjertesvikt osmotisk pumpe isoproterenol mus ekkokardiogram CARDIAC remodeling
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