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Journal / Bioengineering / Organidi neurali umani per lo studio del cancro…
JoVE Journal
Bioengineering

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JoVE Journal Bioengineering
Organidi neurali umani per lo studio del cancro al cervello e delle malattie neurodegenerative
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Organidi neurali umani per lo studio del cancro al cervello e delle malattie neurodegenerative

Article DOI: 10.3791/59682-v • 09:36 min • June 28th, 2019
June 28th, 2019 •
*1, *2, 2, 3, 3, 4, 5, 4, 2
1Laboratory of Tumor Immunology, Translational Research Center in Onco-Hematology, Department of Internal Medicine Specialties, Faculty of Medicine, University of Geneva, 2Department of Pathology and Immunology, University Medical Center, University of Geneva, 3Laboratory of Toxicology and Therapeutic Drug Monitoring, Geneva University Hospitals, 4Tissue Engineering Laboratory, Hepia/HES-SO, University of Applied Sciences Western Switzerland, 5Laboratory of Experimental cell therapy, Department of Diagnostics, Geneva University Hospitals
* These authors contributed equally

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Questo studio introduce e descrive protocolli per derivare due organoidi neurali umani specifici come un modello rilevante e accurato per lo studio 1) lo sviluppo del glioblastoma umano all'interno di organoidi neurali umani esclusivamente negli esseri umani e 2) neuronergico differenziazione generando un organoide tridimensionale.

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Bioingegneria Problema 148 organoide neurale glioblastoma multiforme cellule staminali tumorali cellule staminali embrionali umane neuroni dopaminergici malattia neurodegenerativa
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