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Journal / Developmental Biology / Generation af inducerede neurale stamceller fra…
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JoVE Journal Developmental Biology
Generation af inducerede neurale stamceller fra perifere mononukleære celler og differentiering mod dopaminerge neuron-prækursorer til transplantations studier
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Generation af inducerede neurale stamceller fra perifere mononukleære celler og differentiering mod dopaminerge neuron-prækursorer til transplantations studier

Article DOI: 10.3791/59690-v • 12:13 min • July 11th, 2019
July 11th, 2019 •
1,2, 1,2
1Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, and Key Laboratory of Neurodegeneration, Ministry of Education, 2Center of Neural Injury and Repair, Beijing Institute for Brain Disorders

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Protokollen præsenterer omprogrammering af mononukleære celler i perifert blod for at inducere neurale stamceller ved Sendai-virus infektion, differentiering af iNSCs i dopaminerge neuroner, transplantation af DA-prækursorer til den ensidigt læsionerede Parkinsons sygdom-musemodeller og evaluering af sikkerheden og effekten af iNSC-afledte DA-prækursorer til PD-behandling.

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Udviklingsmæssige biologi neurovidenskab induceret neurale stamceller Parkinsons sygdom omprogrammering differentiering transplantation perifert blod mononukleære celler Sendai virus 6-OHDA dopaminerge neuroner
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