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JoVE Journal
Immunology and Infection

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环境细颗粒物小鼠组织中三种 DNA 损伤的质谱定量及水平评价
 
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环境细颗粒物小鼠组织中三种 DNA 损伤的质谱定量及水平评价

Article DOI: 10.3791/59734-v 12:15 min May 29th, 2019
May 29th, 2019

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Summary

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Click here for the English version.

我们在这里描述的方法敏感和准确定量的病变 8-氧-7-二氢-2 '-脱氧鸟苷 (8-氧 ',1, n6-乙基 2 '-脱氧腺苷 (1,n6-do)和 1,n2-在 DNA 中的乙二-2 '-脱氧鸟苷 (1,n2-dguo)。应用该方法对暴露的阿可姆小鼠组织 (肺、肝、肾) 环境细颗粒物 (PM2.5) 的影响进行了评价。

Tags

免疫学与感染 第147期 质谱、DNA 加合物、DNA 氧化、遗传毒性、氧化应激、细颗粒物
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