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JoVE Journal
Immunology and Infection

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环境细颗粒物小鼠组织中三种 DNA 损伤的质谱定量及水平评价

环境细颗粒物小鼠组织中三种 DNA 损伤的质谱定量及水平评价

Article doi: 10.3791/59734
May 29th, 2019

Summary May 29th, 2019

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我们在这里描述的方法敏感和准确定量的病变 8-氧-7-二氢-2 '-脱氧鸟苷 (8-氧 ',1, n6-乙基 2 '-脱氧腺苷 (1,n6-do)和 1,n2-在 DNA 中的乙二-2 '-脱氧鸟苷 (1,n2-dguo)。应用该方法对暴露的阿可姆小鼠组织 (肺、肝、肾) 环境细颗粒物 (PM2.5) 的影响进行了评价。

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