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Biochemistry

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JoVE Journal Biochemistry
Un modelo de dos colores BLT humanizados con un microbioma intestinal humano estable y un sistema inmune humano
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Un modelo de dos colores BLT humanizados con un microbioma intestinal humano estable y un sistema inmune humano

Article DOI: 10.3791/59773-v • 07:32 min • August 30th, 2019
August 30th, 2019 •
1,2, 1,2, 3, 1,2
1Nebraska Center for Virology, 2School of Biological Sciences, University of Nebraska-Lincoln, 3Department of Food Science and Technology, University of Nebraska-Lincoln

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Describimos un método novedoso para generar ratones BLT dobles humanizados que cuentan con un sistema inmune humano funcional y un microbioma intestinal estable injertado similar al humano. Este protocolo se puede seguir sin necesidad de ratones libres de gérmenes o instalaciones gnotobióticas.

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Bioquímica Número 150 doble humanizado BLT-mice microbioma intestinal inmunidad antibióticos trasplante fecal
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