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Biochemistry

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JoVE Journal Biochemistry
En dobbel Humanisert BLT-mus modell med en stabil human-like gut Mikrobiomet og Human immun system
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En dobbel Humanisert BLT-mus modell med en stabil human-like gut Mikrobiomet og Human immun system

Article DOI: 10.3791/59773-v • 07:32 min • August 30th, 2019
August 30th, 2019 •
1,2, 1,2, 3, 1,2
1Nebraska Center for Virology, 2School of Biological Sciences, University of Nebraska-Lincoln, 3Department of Food Science and Technology, University of Nebraska-Lincoln

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Vi beskriver en ny metode for å generere dobbelt humanisert BLT-mus som har en funksjonell menneskelig immunsystem og en stabil engrafted menneske-lignende gut mikrobiomet. Denne protokollen kan følges uten bakteriefrie mus eller gnotobiotic fasiliteter.

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Biokjemi dobbel humanisert BLT-mus gut mikrobiomet immunitet antibiotika avføring transplantasjon
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