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Journal / Genetics / Karakteriseren van Mutationele belasting en…
JoVE Journal
Genetics

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JoVE Journal Genetics
Karakteriseren van Mutationele belasting en klonale samenstelling van menselijk bloed
A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects (TEdeff) in Cancers
Journal (Genetics)
A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects (TEdeff) in Cancers
DATP-Tailing, Adapter Ligation, and PCR Amplification of Scarce Cell DNA (Video) | JoVE
Journal (Genetics)
DATP-Tailing, Adapter Ligation, and PCR Amplification of Scarce Cell DNA (Video) | JoVE
 
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Karakteriseren van Mutationele belasting en klonale samenstelling van menselijk bloed

Article DOI: 10.3791/59846-v • 07:58 min • July 11th, 2019
July 11th, 2019 •
1, 1, 1, 1
1Princess Máxima Center for Pediatric Oncology

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Click here for the English version.

Somatische mutatie patronen in cellen weerspiegelen de eerdere mutagene blootstelling en kunnen ontwikkelings relaties met de afstamming onthullen. Hier gepresenteerd is een methodologie voor het catalogiseren en analyseren van somatische mutaties in individuele hematopoietische stam-en voorlopercellen.

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Genetica probleem 149 Hematopoiesis clonality somatische mutaties ontwikkeling lineage tracing mutationele handtekeningen leukemie
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