Waiting
Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Genetics / En murine cellelinje baseret model af kronisk…
JoVE Journal
Genetics

A subscription to JoVE is required to view this content.

JoVE Journal Genetics
En murine cellelinje baseret model af kronisk CDK9 hæmning at studere udbredte ikke-genetiske Transkriptional forlængelse defekter (TEabsolut) i kræft
Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Antisense Protein (ASP) RNA Transcripts in Patients by Strand-Specific RT-PCR
Journal (Genetics)
Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Antisense Protein (ASP) RNA Transcripts in Patients by Strand-Specific RT-PCR
Mapping Mammalian 3D Genome Interactions with Micro-C-XL
Journal (Genetics)
Mapping Mammalian 3D Genome Interactions with Micro-C-XL
 
Click here for the English version

En murine cellelinje baseret model af kronisk CDK9 hæmning at studere udbredte ikke-genetiske Transkriptional forlængelse defekter (TEabsolut) i kræft

Article DOI: 10.3791/59910-v • 10:49 min • September 26th, 2019
September 26th, 2019 •
1, 1, 1
1Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center (CCHMC)

Chapters

Summary
Automatic Translation

Please note that all translations are automatically generated.

Click here for the English version.

Protokollen beskriver en in vitro-murine karcinom model af ikke-genetisk defekt transkriptionsforlængelse. Her bruges kronisk hæmning af CDK9 til at undertrykke produktiv forlængelse af RNA pol II langs pro-inflammatoriske respons gener til at efterligne og studere den klinisk overserverede TEabsolut fænomen, til stede i omkring 20% af alle kræfttyper.

Tags

Genetik transskription forlængelse tumor immunologi CDK9 mRNA behandling flavopiridol RNA pol II
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter