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Murine Appendektomie Modell der chronischen Colitis assoziiert entaktischen Darmkrebs durch präzise Lokalisierung von Caecal Patch
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Murine Appendektomie Modell der chronischen Colitis assoziiert entaktischen Darmkrebs durch präzise Lokalisierung von Caecal Patch

Article DOI: 10.3791/59921-v • 08:51 min • August 24th, 2019
August 24th, 2019 •
1, 2,3, 1, 2,3, 1, 4, 1,5, 1,6, 1,2, 1
1Department of General Surgery, The First Affiliated Hospital, Xi'an Jiaotong University, 2Institute of Medical Research, Northwestern Polytechnical University, 3School of Life Sciences, Northwestern Polytechnical University, 4Department of Medicine, Xi'an Jiaotong University, 5Princess Margaret Cancer Center, University of Health Network, 6Department of Pathology, Nanjing Medical University

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Das vorgestellte Protokoll beschreibt eine einfache chirurgische Entfernung des Blinddarms (Kaecal-Patch) in einer Maus, gefolgt von der Induktion von entzündlichem Darmerkrankungen-assoziiertem Dickdarmkrebs. Dieses murine Appendektomie-Modell ermöglicht die Untersuchung der biologischen Rolle des Blinddarms bei der Pathogenese der menschlichen Magen-Darm-Krankheit.

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Medizin Ausgabe 150 murines Modell Blinddarm Kaecal-Patch Magen-Darm-Anatomie Großdarm Tumor IgA Azoxymethan Dextransulfat-Natrium IBD
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