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Journal / Immunology and Infection / Adoptive Immuntherapie von iNKT-Zellen in…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Adoptive Immuntherapie von iNKT-Zellen in Glucose-6-Phosphat-Isomerase (G6PI)-Induzierte RA-Mäuse
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Adoptive Immuntherapie von iNKT-Zellen in Glucose-6-Phosphat-Isomerase (G6PI)-Induzierte RA-Mäuse

Article DOI: 10.3791/60048-v • 08:43 min • January 31st, 2020
January 31st, 2020 •
*1,2, *1,2, *1,2, *1,2, *1,2, *1,2, *1,2, *1,2, *1,2
1Medical School of Hebei University, 2Key Laboratory of Pathogenesis Mechanism and Control of Inflammatory-Autoimmune Diseases in Hebei Province
* These authors contributed equally

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Dieses Protokoll verwendet G6PI gemischte Peptide, um rheumatoide Arthritis-Modelle zu konstruieren, die näher an denen der menschlichen rheumatoiden Arthritis in CD4+ T-Zellen und Zytokinen sind. Hochreine invariante natürliche Killer-T-Zellen (hauptsächlich iNKT2) mit spezifischen Phänotypen und Funktionen wurden durch In-vivo-Induktion und In-vitro-Reinigung zur Adoptivimmuntherapie erhalten.

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Immunologie und Infektion Ausgabe 155 rheumatoide Arthritis Adoptivimmuntherapie iNKT-Zellen Zytokine Glucose-6-Phosphat-Isomerase (G6PI) In-vivo-Bildgebungssystem (IVIS)
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