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Journal / Immunology and Infection / Målrettet antistoff blokkering av en…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Målrettet antistoff blokkering av en dual-funksjonell bøy av antigen peptid og FC-III Mimetics (DCAF)
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Målrettet antistoff blokkering av en dual-funksjonell bøy av antigen peptid og FC-III Mimetics (DCAF)

Article DOI: 10.3791/60063-v • 09:39 min • September 17th, 2019
September 17th, 2019 •
*1,2, *3, 2, 2, 2, 3, 1,2
1Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, 2Mass Spectrometry Core Facility, School of Life Sciences, Westlake University, 3MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University
* These authors contributed equally

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Utvikling av en dual-funksjonell bøy av antigen peptid og FC-III mimetics (DCAF) er romanen for eliminering av skadelige antistoffer. Her beskriver vi en detaljert protokoll for syntesen av DCAF1 molekyl, som kan selektivt blokkere 4G2 antistoff for å eliminere antistoff avhengig ekstrautstyr effekt under Dengue virus infeksjon.

Tags

Tilbaketrekking DCAF målrettet terapi antistoff Native kjemisk ligation solid fase peptid syntese protein uttrykk og rensing ELISA
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