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Journal / Developmental Biology / Riprogrammazione emogenica dei fibroblasti umani…
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Developmental Biology

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JoVE Journal Developmental Biology
Riprogrammazione emogenica dei fibroblasti umani mediante l'espressione forzata dei fattori di trascrizione
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Riprogrammazione emogenica dei fibroblasti umani mediante l'espressione forzata dei fattori di trascrizione

Article DOI: 10.3791/60112-v • 11:42 min • November 4th, 2019
November 4th, 2019 •
1,2,3, 3, 4, 5,6, 1,2,3
1Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, 2Wallenberg Center for Molecular, Lund University, 3Center for Neuroscience and Cell Biology, University of Coimbra, 4Skolkovo Institute of Science and Technology, 5Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 6Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai

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Questo protocollo dimostra l'induzione di un programma emogenico nei fibroblasti dermici umani mediante l'espressione forzata dei fattori di trascrizione GATA2, GFI1B e FOS per generare cellule staminali e progenitrici ematopoietiche.

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Biologia dello sviluppo numero 153 riprogrammazione emogenica fibroblasto fattori di trascrizione ematopoiesi cellule staminali ematopoietiche e progenitrici transizione endotetica-ematopoietica
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