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Journal / Genetics / Akut Miyeloid Lösemi Hücrelerinde CRISPR/Cas9…
JoVE Journal
Genetics

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JoVE Journal Genetics
Akut Miyeloid Lösemi Hücrelerinde CRISPR/Cas9 Ribonükleoprotein ile RUNX1 Intronic Susturucunun Transkripsiyonel Rolünün İncelendirin
CRISPR/Cas9-mediated Targeted Integration In Vivo Using a Homology-mediated End Joining-based Strategy
Journal (Genetics)
CRISPR/Cas9-mediated Targeted Integration In Vivo Using a Homology-mediated End Joining-based Strategy
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Journal (Genetics)
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Akut Miyeloid Lösemi Hücrelerinde CRISPR/Cas9 Ribonükleoprotein ile RUNX1 Intronic Susturucunun Transkripsiyonel Rolünün İncelendirin

Article DOI: 10.3791/60130-v • 09:16 min • September 1st, 2019
September 1st, 2019 •
1, 1, 1, 1, 1,2
1Blood Cancer Cytogenetics and Genomics Laboratory, Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, 2State Key Laboratory in Oncology in South China, The Chinese University of Hong Kong

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Önceden monte edilmiş Cas9/guide RNA ribonükleoprotein komplekslerinin doğrudan teslimi hematopoetik hücrelerde genom düzenleme için hızlı ve etkili bir araçtır. Burada, bir RUNX1 intronic susturucu silmek ve OCI-AML3 lökemik hücrelerde transkripsiyonel yanıtları incelemek için bu yaklaşımı kullanır.

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Genetik Sayı 151 CRISPR/CAS9 ribonükleoprotein elektroporasyon cis-düzenleyici element susturucu Transkripsiyonel kontrol lösemi
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