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JoVE Journal Cancer Research
Diferenciação das células Epiteliais do Peito do Camundongo HC11 e EpH4
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Diferenciação das células Epiteliais do Peito do Camundongo HC11 e EpH4

Article DOI: 10.3791/60147-v • 09:32 min • February 27th, 2020
February 27th, 2020 •
*1,2, *1, *1,3, 1,4, 1, 1, 2, 1
1Department of Biomedical and Molecular Sciences and Department of Pathology and Molecular Medicine, Queen's University, Kingston, 2Department of Chemical and Physical Sciences, University of Toronto, Mississauga, 3Department of Laboratory Medicine, Brampton Civic Hospital Campus, William Osler Health System, 4Latner Thoracic Surgery Research Laboratories
* These authors contributed equally

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Descrevemos técnicas de indução de diferenciação de duas linhas epiteliais mamárias, HC11 e EpH4. Embora ambos exijam soro fetal, insulina e prolactina para produzir proteínas lácteas, as células EpH4 podem se diferenciar totalmente das mamografias na cultura tridimensional. Esses modelos complementares são úteis para estudos de transdução de sinal de diferenciação e neoplasia.

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Pesquisa do Câncer Edição 156 diferenciação celular células epiteliais mamárias prolactina matriz eHS
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