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Et mikrofysiologisk system for lægemiddelmakokinetisk og toksikologisk vurdering af tarmen/leversystemet
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Et mikrofysiologisk system for lægemiddelmakokinetisk og toksikologisk vurdering af tarmen/leversystemet

Article DOI: 10.3791/60184-v • 08:59 min • December 3rd, 2020
December 3rd, 2020 •
1, 4, 1, 1,2, 1, 1, 1, 3, 3, 1
1Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), 2Brazilian Synchrotron Light Laboratory (LNLS), Brazilian Center for Research in Energy and Materials (CNPEM), 3Grupo Boticário, 4Institute of Biology, University of Campinas

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Vi udsatte et mikrofysiologisk system (MPS) med tarm og leverorganoider for acetaminophen (APAP). I denne artikel beskrives metoderne til organoidproduktion og APAP-farmakoketiske og toksikologiske ejendomsvurderinger i mps.' en. Den beskriver også de vævsfunktionsanalyser, der er nødvendige for at validere resultaterne.

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Kemi Problem 166 Mikrofysiologisk System Acetaminophen ADMETox Organoids
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