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JoVE Journal Chemistry
Et mikrofysiologisk system for farmakokinetisk og toksikologisk vurdering av tarmen/leveren
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Et mikrofysiologisk system for farmakokinetisk og toksikologisk vurdering av tarmen/leveren

Article DOI: 10.3791/60184-v • 08:59 min • December 3rd, 2020
December 3rd, 2020 •
1, 4, 1, 1,2, 1, 1, 1, 3, 3, 1
1Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), 2Brazilian Synchrotron Light Laboratory (LNLS), Brazilian Center for Research in Energy and Materials (CNPEM), 3Grupo Boticário, 4Institute of Biology, University of Campinas

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Vi eksponerte et mikrofysiologisk system (MPS) med tarm- og leverorganoider for paracetamol (APAP). Denne artikkelen beskriver metodene for organoid produksjon og APAP farmakokinetiske og toksikologiske eiendomsvurderinger i MPS. Den beskriver også vevfunksjonsanalysene som er nødvendige for å validere resultatene.

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Kjemi utgave 166 Mikrofysiologisk system Paracetamol ADMETox Organoider
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