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Un sistema microfisiológico intestinal/hepático para la evaluación farmacocinética y toxicológica de fármacos
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Un sistema microfisiológico intestinal/hepático para la evaluación farmacocinética y toxicológica de fármacos

Article DOI: 10.3791/60184-v • 08:59 min • December 3rd, 2020
December 3rd, 2020 •
1, 4, 1, 1,2, 1, 1, 1, 3, 3, 1
1Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), 2Brazilian Synchrotron Light Laboratory (LNLS), Brazilian Center for Research in Energy and Materials (CNPEM), 3Grupo Boticário, 4Institute of Biology, University of Campinas

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Hemos expuesto un sistema microfisiológico (MPS) con organoides intestinales y hepáticos al paracetamol (APAP). Este artículo describe los métodos para la producción de organoides y las evaluaciones de propiedades farmacocinéticas y toxicológicas APAP en el MPS. También describe los análisis de funcionalidad tisular necesarios para validar los resultados.

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Química Número 166 Sistema Microfisiológico Paracetamol ADMETox Organoides
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