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JoVE Journal Chemistry
En tarm/lever Microphysiological System för Drug Farmakokinetiska och Toxikologiska Bedömning
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En tarm/lever Microphysiological System för Drug Farmakokinetiska och Toxikologiska Bedömning

Article DOI: 10.3791/60184-v • 08:59 min • December 3rd, 2020
December 3rd, 2020 •
1, 4, 1, 1,2, 1, 1, 1, 3, 3, 1
1Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), 2Brazilian Synchrotron Light Laboratory (LNLS), Brazilian Center for Research in Energy and Materials (CNPEM), 3Grupo Boticário, 4Institute of Biology, University of Campinas

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Vi utsatt ett microphysiological system (MPS) med tarmen och lever organoider till paracetamol (APAP). Den här artikeln beskriver metoderna för organoid produktion och APAP farmakokinetiska och toxikologiska egendom bedömningar i MPS. Den beskriver också de vävnadsfunktionsanalyser som är nödvändiga för att validera resultaten.

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Kemi Mikrofysiologiskt system Paracetamol ADMETox Organoider
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