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JoVE Journal Chemistry
Solid phase 11C-methylering, zuivering en formulering voor de productie van Pet-tracers
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Solid phase 11C-methylering, zuivering en formulering voor de productie van Pet-tracers

Article DOI: 10.3791/60237-v • 09:25 min • October 24th, 2019
October 24th, 2019 •
*1, *1, 1, 1, 1, 1,2
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 2Department of Neurology and Neurosurgery, McGill University
* These authors contributed equally

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We rapporteren een efficiënte Carbon-11 radiolabeling-techniek om klinisch relevante tracers te produceren voor positron emissie tomografie (PET) met behulp van Solid phase-extractie cartridges. 11 C-methylating agent wordt doorgegeven via een patroon vooraf geladen met precursor en opeenvolgende elutie met waterige ethanol biedt chemisch en radiochemisch zuivere PET tracers in hoge radiochemische opbrengsten.

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Scheikunde uitgave 152 Carbon-11 radiolabeling positron emissie tomografie beeldvorming [11c] PIB [11c] ABP688 11c-methylatie Solid phase ondersteunde synthese Solid phase extractie automatisering
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