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Neuroscience

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JoVE Journal Neuroscience
Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System
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Intrathecal Delivery of Antisense Oligonucleotides in the Rat Central Nervous System

Article DOI: 10.3791/60274-v • 07:47 min • October 29th, 2019
October 29th, 2019 •
*1, *2, *1, 1, 1, 1, 1
1Biogen, Inc., 2Ionis Pharmaceuticals
* These authors contributed equally

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Summary
Automatic Translation

Here, we describe a method for delivering drugs to the rat central nervous system by implanting a catheter into the lumbar intrathecal space of the spine. We focus on the delivery of antisense oligonucleotides, though this method is suitable for delivery of other therapeutic modalities as well.

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Intrathecal Delivery Antisense Oligonucleotides Rat Central Nervous System Pharmacokinetics Pharmacodynamics Efficacy Therapeutics Disease Models Guide Cannulas Catheter Wire Assembly Intrathecal Catheter Delivery Catheter Assembly PE10 Tubing PE50 Catheter
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