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JoVE Journal Neuroscience
Intrathecal levering af antisense oligonukleotider i rat central nerve system
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Intrathecal levering af antisense oligonukleotider i rat central nerve system

Article DOI: 10.3791/60274-v • 07:47 min • October 29th, 2019
October 29th, 2019 •
*1, *2, *1, 1, 1, 1, 1
1Biogen, Inc., 2Ionis Pharmaceuticals
* These authors contributed equally

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Her beskriver vi en metode til at levere medicin til rat centralnervesystemet ved at implantering af et kateter i lænde intrathecale rum af rygsøjlen. Vi fokuserer på levering af antisense oligonucleotides, men denne metode er også egnet til levering af andre terapeutiske modaliteter.

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Neurovidenskab problem 152 antisense oligonukleotider blodhjernebarriere centralnervesystemet intratalleve ring rotte RNA rygmarv
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