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Un flujo de trabajo de integración de datos para identificar combinaciones de fármacos dirigidas a interacciones letales sintéticas
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Un flujo de trabajo de integración de datos para identificar combinaciones de fármacos dirigidas a interacciones letales sintéticas

Article DOI: 10.3791/60328-v • 08:04 min • May 27th, 2021
May 27th, 2021 •
1, 2, 1, 3, 1
1Department of Internal Medicine I - Division of Oncology, Comprehensive Cancer Center, Medical University of Vienna, 2Department of Nephrology, Medical University of Vienna, 3Department of Internal Medicine IV, Medical University Innsbruck

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Las pantallas genéticas grandes en organismos modelo han llevado a la identificación de interacciones genéticas negativas. Aquí, describimos un flujo de trabajo de integración de datos utilizando datos de pantallas genéticas en organismos modelo para delinear combinaciones de fármacos dirigidas a interacciones letales sintéticas en el cáncer.

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Cancer Research synthetic lethality genetic screens data integration homology mapping drug combinations breast cancer treatment cell viability assay
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