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Journal / Genetics / Kortlægning af Alzheimers sygdom varianter til…
JoVE Journal
Genetics

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JoVE Journal Genetics
Kortlægning af Alzheimers sygdom varianter til deres Målgener ved hjælp af beregningsmæssige analyse af kromatin konfiguration
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Kortlægning af Alzheimers sygdom varianter til deres Målgener ved hjælp af beregningsmæssige analyse af kromatin konfiguration

Article DOI: 10.3791/60428-v • 04:41 min • January 9th, 2020
January 9th, 2020 •
1,2, 3, *3,4, *1,2
1Department of Genetics, University of North Carolina, 2Neuroscience Center, University of North Carolina, 3Thurston Arthritis Research Center, University of North Carolina, 4Department of Cell Biology and Physiology, University of North Carolina
* These authors contributed equally

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Vi præsenterer en protokol til at identificere funktionelle konsekvenser af ikke-kodning varianter identificeret ved genomdækkende Association undersøgelser (GWAS) ved hjælp af tredimensionelle kromatin interaktioner.

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Genetik udstedelse 155 Hi-C GWAS ikke-kodning varianter genkort lægning funktionel Genomics Alzheimers sygdom
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