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JoVE Journal Cancer Research
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Article DOI: 10.3791/60445-v • 04:12 min • December 19th, 2019
December 19th, 2019 •
*1, *1, 1,2, 1,2, 1
1Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, 2Department of Clinical Microbiology, Fimlab Laboratories
* These authors contributed equally

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Summary
Automatic Translation

Two-stage skin carcinogenesis is induced by two topically applied chemicals. A mutagen 7,12-dimethylbenz[a]anthracene) causes mutations in the epidermal cells and a continuous application of general growth stimulator 12-O-tetradecanoyl phorbol-13-acetate accelerates skin papilloma formation.

Tags

Chemical-induced Skin Carcinogenesis Model DMBA-TPA Inflammation In Skin Cancer Tumor Initiation Tumor Progression Knockout Strains Environmental Factors Therapeutic Candidates Immune System Angiogenesis Squamous Cell Carcinoma Disease Pathology Safety Measures DMBA Handling Aggressive Mice Separate Cages Skin Papilloma Induction DMBA Application TPA Treatment Papillomas Size
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