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JoVE Journal Cancer Research
Modello di carcinogenesi cutanea indotta dalla sostanza chimica utilizzando Dimethylbenz[a]Anthracene e 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
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Modello di carcinogenesi cutanea indotta dalla sostanza chimica utilizzando Dimethylbenz[a]Anthracene e 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)

Article DOI: 10.3791/60445-v • 04:12 min • December 19th, 2019
December 19th, 2019 •
*1, *1, 1,2, 1,2, 1
1Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, 2Department of Clinical Microbiology, Fimlab Laboratories
* These authors contributed equally

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La carcinogenesi cutanea a due stadi è indotta da due sostanze chimiche applicate topicamente. Un mutagen 7,12-dimethylbenz[a]anthracene) provoca mutazioni nelle cellule epidermiche e una continua applicazione dello stimolatore di crescita generale 12-O-tetradecanoyl phorbol-13-acetato accelera la formazione di papilloma cutaneo.

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Ricerca sul cancro Problema 154 Cancro della pelle cancerogenesi chimica mutageno promotore DMBA-TPA papilloma angiogenesi infiammazione tumore proliferazione
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