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En råtta halsartären tryckkontrollerad segmental ballong skada med periadventitial terapeutisk tillämpning
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En råtta halsartären tryckkontrollerad segmental ballong skada med periadventitial terapeutisk tillämpning

Article DOI: 10.3791/60473-v • 06:53 min • July 9th, 2020
July 9th, 2020 •
1,2,3,5, 1,2,3,4,5
1Department of Surgery, Division of Vascular Surgery, University of North Carolina at Chapel Hill, 2Center for Nanotechnology in Drug Delivery, University of North Carolina at Chapel Hill, 3Curriculum in Toxicology & Environmental Medicine, University of North Carolina at Chapel Hill, 4Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, 5McAllister Heart Institute, University of North Carolina at Chapel Hill

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Råtta halsartären ballong skada efterliknar kliniska angioplastik förfarande utförs för att återställa blodflödet i åderförkalkning fartyg. Denna modell inducerar kranskärlens skada svar genom att distending kranskärlens väggen, och denuding intimal skiktet av endotelceller, i slutändan orsakar ombyggnad och en intimal hyperplastic svar.

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Medicin Utgåva 161 Råtta halsartären Ballongskada Kärlskada Restenosis Neointimal Hyperplasi Periadventitial Drug Delivery Arterial Injury Response Vessel Remodeling Cardiovascular Disease Peripheral Artery Disease Vaskulär Smooth Muscle Cell Light Sheet Fluorescent Microscopy
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