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Uma lesão de balão segmental controlada por pressão da artéria de rato com aplicação terapêutica periadventicional
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Uma lesão de balão segmental controlada por pressão da artéria de rato com aplicação terapêutica periadventicional

Article DOI: 10.3791/60473-v • 06:53 min • July 9th, 2020
July 9th, 2020 •
1,2,3,5, 1,2,3,4,5
1Department of Surgery, Division of Vascular Surgery, University of North Carolina at Chapel Hill, 2Center for Nanotechnology in Drug Delivery, University of North Carolina at Chapel Hill, 3Curriculum in Toxicology & Environmental Medicine, University of North Carolina at Chapel Hill, 4Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, 5McAllister Heart Institute, University of North Carolina at Chapel Hill

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A lesão do balão carótida do rato imita o procedimento clínico de angioplastia realizado para restaurar o fluxo sanguíneo em vasos ateroscleróticos. Este modelo induz a resposta à lesão arterial distending da parede arterial, e desnuding a camada intimal de células endoteliais, causando, em última análise, remodelação e uma resposta hiperplástica intimal.

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Medicina Edição 161 Artéria Carótida de Rato Lesão do Balão Lesão Vascular Restenose Hiperplasia Neointimal Entrega de Medicamentos Periadventiais Resposta de Lesão Arterial Remodelagem de Vasos Doença Cardiovascular Doença Arterial Periférica Célula Muscular Liso Vascular Microscopia Fluorescente Folha Leve Fluorescente
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